Drill Disease is a strange space disease. Keroro is the first to be infected by it, according to Kururu, this disease is contagious, capable of infecting the victims those who get touched or hit by a drill. The cure for the disease is to use "Aiho Roll", seen by Pururu.

If infected by a disease, an infected host utters "Ana horu!" (In the English version, they uttered "Dig a hole!").

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